nevirapine will minimize the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
modafinil will decrease the extent or impact of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Check Closely (1)triclabendazole will enhance the level or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism.
crizotinib increases amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Dose reduction could be essential for coadministered drugs which are predominantly metabolized by CYP3A.
Use modafinil throughout pregnancy with caution if Added benefits outweigh challenges. Animal research display danger and human scientific studies will not be out there, or neither animal nor human research had been done.
Modafinil is made use of to take care of lots of sleepiness that will transpire with slumber apnea, narcolepsy, or shift function difficulties.
Continue to, simultaneously, The reality that it's certainly a strong drug that could have some severe Unwanted side effects, and also to which Every person responds differently.
Not advisable in clients with angina, cardiac ischemia, and recent heritage of myocardial infarction, still left ventricular hypertrophy or mitral valve prolapse
apalutamide will lower the extent or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medication which might be CYP3A4 substrates may end up in decrease exposure to these medicines.
modafinil will improve the level or result of rabeprazole by influencing hepatic enzyme CYP2C19 metabolism. Slight/Significance Unfamiliar. Internet impact on pantoprazole steps unidentified resulting from opposing results of CYP450 enzymes; watch
apalutamide will minimize the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with prescription drugs that happen to be CYP3A4 substrates can result in decreased exposure to those medications.
It really is Obviously a chance that modafinil could immediately act on enzymes within the Mind’s cost-free-radical scavenging procedure (eg, glutathione peroxidase or website superoxide dismutase) to instantly lower totally free-radical levels. Simply because, reactive oxygen species feed back again positively about the mitochondrion to scale back ATP production and possibly improve free radical manufacturing (Echtay et al 2002; Brookes et al 2004), such a system could also account for modafinil’s capability to improve the cortical creatine-phosphocreatine pool (Pierard et al 1995).
Medications that demand prior authorization. This restriction needs that unique scientific conditions be met before the approval from the prescription.
sparsentan will minimize the level or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and minimizes efficacy linked to these substrates.